摘要
目的了解鲍氏不动杆菌的临床分布及对常用抗菌药物的耐药性变迁趋势,为指导临床合理用药提供理论依据。方法回顾性分析2005-2009年厦门大学附属中山医院临床分离的1967株鲍氏不动杆菌药敏结果。结果医院鲍氏不动杆菌的分离率呈逐年增长趋势,由2005年的110株上升至2009年的1040株,标本来源以痰液为主,占87.5%;对抗菌药物的耐药率也日趋严重,其中庆大霉素、左氧氟沙星及亚胺培南的耐药率分别由2005的38.2%、17.3%及2.7%上升至2009年的68.9%、67.0%及68.8%;头孢哌酮/舒巴坦、氨苄西林/舒巴坦、哌拉西林/他唑巴坦和多黏菌素B耐药率较低。结论鲍氏不动杆菌在临床的分离率逐年增加,耐药性逐渐增强。
OBJECTIVE To study the changing trends of drug resistance of Acinetobacter baurnannii isolates. METHODS The bacterial susceptibility results of 1 967 isolates of A. baumannii obtained from clinical patients in the Zhongshan Hospital of Xiamen University between 2005 and 2009 were retrospectively analyzed. RESULTS The isolating rate of A. baurnannii was increasing year-by-year from 110 in 2005 to 1040 in 2009, the highest appearing rate was the sputum, up to 87. 5M. The resistant rates of A. baumannii to antibacterial drugs were increasing year by year. The resistant rates to gentamicin, levofloxacin and imipenem were increasing from 38.2%, 17. 3M and 2. 7% to 68. 9%,67. 0% and 68. 8%, respectively. The resistant rates to cefoperazone/ sulbactam,ampicillin/sulbactam,piperacillin/sulbactam and polymyxin B. were low. CONCLUSIONS The isolation rate of ABA from clinics is increased year by year, and the resistance gradually becomes serious.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第24期5274-5276,共3页
Chinese Journal of Nosocomiology
关键词
鲍氏不动杆菌
抗菌药物
耐药性
Acinetobacter baumannii
Antimicrobial agents
Drug resistance
