医院感染病原菌分布及药物敏感性监测

Distribution of pathogens causing nosocomial infection and surveillance for drug susceptibility

目的了解医院感染病原菌分布及药物敏感性,以指导临床合理用药。方法总结分析2006年6月-2010年6月医院临床各类标本培养分离出的病原菌分布及对抗菌药物的敏感性。结果分离病原菌2624株,其中革兰阴性杆菌占60.8%,革兰阳性球菌占24.3%,真菌占14.9%;产ESBLs大肠埃希菌、肺炎克雷伯菌株检出率分别为48.6%、46.7%;MRSA检出率为45.5%,MRCNS检出率为42.5%;VRE检出率为5.7%。结论为减少医院感染和耐药菌株的传播,应加大细菌培养力度,尽可能选用合理抗菌药物。

OBJECTIVE To investigate the distribution and dug resistance of nosocomial infection （NI）pathogens and provide the basis for clinical prevention and treatment. METHODS Statistical methods were used to analyze the data of pathogens origin and drug resistance from Jan 2006 to Jun 2010. RESULTS Altogether 2624 strains bacteria were isolated. Among the pathogens, G-pathogens accounted for 60.8%, G＋ cocci 24.3%, and fungi 14.9%. The isolating rates of ESBLs-producing E. coli and K. pneumonia were 48.6% and 46.7%. The prevalence of MRSA and MRSCN were 45.6% and 42.5% respectively. The prevalence of VRE was 5.7%. CONCLUSION It should pay attention to promote the rational use of antimicrobial agents and take effective measures to reduce resistance rates of bacteria.