白族地区不孕不育患者支原体属感染及药敏分析

Mycoplasma infections in infertility patients of Bai nationality and drug susceptibility test

目的了解大理白族地区不孕不育患者支原体属感染率及其药物敏感性,指导临床合理使用抗菌药物,提高治疗效果。方法对983例不孕不育患者的生殖道分泌物标本进行培养、鉴定及药敏试验,并对支原体属的药敏率进行分析。结果 983例不孕不育就诊患者中,支原体属培养阳性868例,阳性率为88.30%,其中解脲脲支原体(Uu)715例,占82.37%,人支原体(Mh)31例,占3.57%,Uu、Mh混合感染122例,占14.06%;支原体属对交沙霉素最敏感,对环丙沙星、氧氟沙星的耐药性较高。结论大理白族地区不孕不育患者中支原体属的检出率较高,主要以Uu为主,也有Uu、Mh混合感染;交沙霉素等新一代抗菌药物为支原体属感染的首选药物。

OBJECTIVE To understand the proportion of infertility patients with mycoplasma infection in Dali Bai nationality and its drug sensitivity, to guide antibiotics rationally and improve the therapy effectively. METHODS A total of 983 specimens with the secretions of infertility were cultured, identification and susceptibility test were made, and the drug resistance of Mycoplasma was analyzed. RESULTS Of 983 specimens, 868 cases were positive mycoplasma, accounting for 88.30%, of which Ureaplasma urealyticum （Uu） positive in 715 cases accounted for 82.37%, Mycoplasma hominis （Mh）positive in 31 cases accounted for 3.57%, and 122 cases were Uu, Mh mixed infections accounted for 14. 06%, Mycoplasma is sensitive to josamycin most, and have a higher resistance to ciprofloxacin and ofloxacin. CONCLUSIONS Mycoplasma have higher detection rates in infertility patients of Dali Bai nationality, and the infections are mainly caused by Uu, partly were Uu, Mh mixed inflection. New generation of antibiotics such as josamycin, is the first remedy for mycoplasma infection.