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阿尔茨海默病发生机制的研究进展 被引量:13

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摘要 阿尔茨海默病(Alzheimer's disease,AD),是一种持续性神经功能障碍。1906年I1月3日,在德国Tfibingen的一次会议上,巴伐利亚精神病学家Alois Alzheimer首次描述了随后以其名字命名的一种神经退行性综合症的病理特征,即AD,
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第24期4997-4998,共2页 Chinese Journal of Gerontology
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参考文献19

  • 1Goedert M, Spillantini MG. A century of Alzheimer' s disease [J].Science,2006 ;314 (5800) :777-81.
  • 2Frosch MP, Anthony DC, Girolami UD. The central nervous system:degenerative disease. In : Kuman V, Abbas AK, Fanston (Ed). Robbins and Cotran Pathologic Basis of Disease [ J ]. Philadelphia: Elsevier Saunders, 2005 ; 1347-420.
  • 3马小骏,刘新英,吴浩一,韩鸿宾,樊东升,崔德华.分子影像学在阿尔茨海默症研究中的进展和应用[J].神经疾病与精神卫生,2008,8(1):2-4. 被引量:4
  • 4Pric DL, Sisodia SS. Mutant genes in familial Alzheimer's disease and transgenic models [ J ]. Annu Rev Neuorsci, 1998 ;21 ( 5 ) :479 -505.
  • 5Kang J, Lemaire HG, Unterbeck A, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor [ J ]. Nature, 1987 ;325 (6106) :733-6.
  • 6Tanzi RE, Gusella JF, Watkins PC, et al. Amyloid β protein gene:cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus [ J]. Science, 1987 ;235 (4791) :880-4.
  • 7Shoji M, Golde TE, Ghiso J,et al. Production of the Alzheimer amyloid β protein by normal proteolytic processing[ J ]. Science, 1992 ;258 ( 5079 ) : 126-9.
  • 8Asami-Odaka A, Ishibashi Y, Kikuchi T, et al. Long amyloid β-protein secreted from wilde-type human neuroblastoma IMR-32 cells [ J]. Biochemistry, 1995 ;34 (32) : 10272-8.
  • 9Burdick D, Soreghan B, Kwon M, et al. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs [ J ]. J Biol Chem,1992;267 ( 1 ) :546-54.
  • 10Roher AE, Lowenson JD, Clarke S, et al. Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease[ J]. J Biol Chem, 1993 ;268 (5) :3072-83.

二级参考文献52

  • 1郝晶,李坤成,李可,张德玄,王葳,闫镔,杨延辉,王岩.Alzheimer病视觉注意缺陷的功能MRI研究[J].中华放射学杂志,2005,39(5):453-458. 被引量:14
  • 2刘毅,崔德华.脑脊液标记物在阿尔茨海默氏病诊断中的应用[J].神经疾病与精神卫生,2007,7(3):165-168. 被引量:3
  • 3Connor JR, Menzies SL, St Martin SM,et al. A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains [J]. J Neurosci Res,1992;31 ( 1 ) :75-83.
  • 4Grundke-Iqbal I, Fleming J, Tung YC,et al. Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia[J]. Acta Neuropathol, 1990 ;81 (2) : 105-10.
  • 5Bartzokis G,Sultzer D, Mintz J,et al. In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI[J]. Biol Psychiatry, 1994 ;35 ( 7 ) :480-7.
  • 6House MJ,St Pierre TG,Foster JK,et al. Quantitative MR imaging R2 relaxometry in elderly participants reporting memory loss [J]. AJNR Am J Neuroradiol,2006 ;27 ( 2 ) :430-9.
  • 7Quintana C,Wu TD, Delatour B,et al. Morphological and chemical studies of pathological human and mice brain at the subcellular level:correlation between light,electron, and nanosims microscopies [J]. Microsc Res Tech,2007 ;70(4) :281-95.
  • 8Palmer AM,Burns MA. Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer' s disease [J]. Brain Res, 1994 ; 645 (1-2) :338-42.
  • 9Turnbull,,S,Tabner B J, El-Agnaf OM, et al. New evidence that the Alzheimer beta-amyloid peptide does not spontaneously form free radicals: an ESR study using a series of spin-traps[J]. Free Radic Biol Med,2001 ; 30(10) :1154-62.
  • 10Smith MA, Harris PL, Sayre LM, et al. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals [J]. Proc Natl Acad Sci U S A, 1997 ;94 ( 18 ) :9866-8.

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