多环麝香中间体六甲基茚满的催化合成

Catalytic Synthesis of Hexamethyl Indane-Intermediate of Polycyclic Musk

以对伞花烃为原料,叔戊醇作烷基化试剂,对合成多环麝香中间体1,1,2,3,3,5-六甲基茚满反应的催化剂种类及影响因素进行对比研究。结果表明:以自制Fe2(SO4)3/AlCl3固体超强酸为催化剂,用量为10%,对伞花烃与叔戊醇的摩尔比为2.0∶1.0,反应温度为8℃,滴加反应时间为2.5 h,六甲基茚满的产率最高,为15.88%。

The types of catalysts and influencing factors were studied in the synthesis of 1,1,2,3,3,5-hexamethyI indane, using p-cymene as raw material and tert-amyl alcohol as alkylation reagent. The maximum yield of 1,1,2,3,3,5-hexamethylindane （15.88%） were obtained as the dosage of the self-made Fe2（ SO4 ）3/AlCl3 solid superaeid catalyst 10%, the molar ratio of p-eymene to tert-amyl alcohol 2.0 ： 1.0, reaction temperature 8 degrees C, and the reaction time 2.5 h.