Cu(Ⅱ)配合物荧光探针用于NO检测

Copper(Ⅱ) fluorescent probe for detecting nitric oxide

一氧化氮(NO)是体内普遍存在的信号分子,参与了众多复杂的生理过程,在神经传导、能量代谢、免疫应答、炎症反应和肿瘤的发生发展中扮演了重要角色,检测NO具有十分重要的研究意义。目前检测NO的常规技术并不能用于体内实时、直观地检测NO水平,应用受到限制。本文综述了Cu(Ⅱ)配合物类NO荧光探针的研究进展,可用于细胞和动物体内NO水平的测定。

Nitric oxide（NO） is a ubiquitous signaling molecule,which takes an important part in various complicated physiological process,such as neurotransmission,energy metabolism,immune response,inflammatory response and tumorigenesis.Therefore,the detection of NO is of great significance.The conventional methods of NO detection are not able to determine NO level in vivo at a real-time scale and the application of these methods are frequently restricted.In this review,we focus on the development of copper（Ⅱ） compound-derived NO fluorescent probes that have been comprehensively used for the determination of NO level in the cultured cells and in vivo.