药物潜在毒性发现技术及其在中药安全性评价中的应用展望

Research progress on discovery of drug potential toxicity and perspective on safety evaluation of Chinese materia medica

随着科学技术的不断发展,人类发现新化合物的种类和数量不断增加,但这些化合物最终成为药品到上市销售是一个周期长、操作复杂、资金投入大且失败率很高的过程。因此,寻找能够确切、快速、敏感反映外源性化合物对生物体毒性作用的安全性评价模型已成为现代药学研究的热点。近年来不断涌现出应用各种先进的生物学手段及平台进行药物毒性评价的方法,这些方法在一定程度上克服了传统毒理学药物毒性评价的缺点,不仅为药物安全性评价及应用奠定了基础,同时也节约了大量的人力、物力和财力。就药物毒性预测及潜在毒性评价方法进行综述,并对其在中药安全性评价方面的应用前景进行展望。

Following the development of science and technology,the number and variety of newly discovered compounds are increasing.However,it is a long process for the new compounds to become clinic medicines into the market eventually as well as be costly and difficult to manipulate with high failure rate.So it has been a hot point of modern pharmacy to set up a precise,fast,and sensitive model to evaluate the toxic effect of exogenous compounds on bio-organism.In recent years,large members of advanced biological methods and platforms for evaluating the drug toxicity have been put into use constantly.These methods not only overcome the shortcomings of traditional toxicology and lay the foundation for drug safety evaluation,but also save a lot of mannal labour,material resources,and financial resources.In this paper,we are going to review on the methods of drug toxicity predetermination and potential toxicity evaluation and also give an overlook of their application on the safety evaluation of CMM.