乙酰氧基胡椒酚乙酸酯亚微乳的制备及其性质考察

Preparation of 1′-acetoxychavicol acetate submicron emulsion and investigation of its properties

目的制备乙酰氧基胡椒酚乙酸酯亚微乳剂并考察其性质。方法采用高压微射法制备乙酰氧基胡椒酚乙酸酯亚微乳,优化处方和制备工艺,考察其粒径、电位、载药量和稳定性。结果制备的乙酰氧基胡椒酚乙酸酯亚微乳粒径和Zeta电位分别为(175.03±4.28)nm和(?30.80±0.44)mV,载药量为877.3μg/mL,在低温避光条件下保存稳定性良好。结论制备的乙酰氧基胡椒酚乙酸酯亚微乳粒径小、含药量高,稳定性良好,为乙酰氧基胡椒酚乙酸酯的制剂研究提供参考。

Objective To investigate the preparation of 1′-acetoxychavicol acetate（ACA） submicron emulsion and its properties.Methods ACA submicron emulsion was prepared using high pressure homogenization technique.The formulation and preparation technique were optimized,the particle size,Zeta potential,content,and stability were tested.Results The mean diameter and Zeta potential of ACA submicron emulsion were（175.03 ± 4.28） nm and（？30.80 ± 0.44） mV,respectively.The loading drug amount is about 877.3 μg/mL with a good stability when stored in low-temperature and away from light.Conclusion The prepared ACA submicron emulsion has a small size particals,high content,and good stability.This method can provide some basis and study on preparation of ACA.