子宫内膜间质肉瘤的形态及免疫组化分析

MORPHOLOGIC AND IMMUNOHISTOCHEMICAL ANALYSIS OF ENDOMETRIAL STROMAL SARCOMA

目的 研究子宫内膜间质肉瘤（ＥｎｄｏｍｅｔｒｉａｌＳｔｒｏｍａｌＳａｒｃｏｍａ，ＥＳＳ） 的组织学形态和免疫组化表达。 方法 应用常规ＨＥ染色、免疫组化标记和组化染色对１６ 例ＥＳＳ及１０ 例正常子宫内膜、肌组织进行回顾性研究。 结果 ＥＳＳ细胞的组织形态、免疫组化和组化染色表达与正常子宫内膜间质细胞相似，部分ＥＳＳ及正常子宫内膜间质细胞中ａｃｔｉｎ 表达阳性。 结论 ＥＳＳ的组织发生来自子宫内膜间质细胞，ＥＳＳ及子宫内膜间质细胞具有向平滑肌分化的能力。ＥＳＳ与平滑肌肿瘤的鉴别诊断主要根据各自的形态特点，肌源性标记呈强阳性，以及Ｍａｓｓｏｎ 三色染色显示红色反应。

PURPOSE To provide the morphologic and immunohistochemical analysis of endometrial stromal sarcoma(ESS).METHODS Sixteen cases of ESS and ten cases of normal endometrium and myometrium were studied using routine HE staining, immunohistochemical and histochemical methods.RESULTS ESS was similar to normal endometrial stromal cells in morphology and immunostaining.Some cases of ESS and endometrial stromal cells expressed muscle related antigens.CONCLUSIONS ESS may be dirived from endometrical stromal cells.ESS and endometrial stromal cells had smooth muscle differentiation.Morphologic features were effective in distinguishing between ESS and uterine leiomyosarcoma.Uterine leiomyosarcoma is characterized by strong positive staining of anti smooth muscle antibody and red of Masson′s staining.