干燥综合征与粘膜相关型淋巴瘤临床病理分析

Clinicopathological study of Sjogren's syndrome and mucosa-associated lymphoid tissue lymphoma

目的：探讨干燥综合征（SS）病理分析对诊断SS的意义及SS、Mikulicz病与粘膜相关淋巴组织（MALT）型淋巴瘤的关系。方法：回顾性分析159例经病理证实的SS，对疑为MALT型淋巴瘤的6例用免疫组化ABC法标记，使用抗体LCA、bcl．2、UCHL－1、L26及免疫球蛋白IgG、IgA、IgM、IgD、lgE和κ、λ。结果：6例可疑病例中有4例发生MALT型淋巴瘤，免疫组化LCA、L26、bcl－2、IgM、κ和IgM、λ呈阳性。结论：①下唇粘膜、泪腺、腮腺活检进行病理分级对于诊断SS有重要意义；②MALT型淋巴瘤的发生与SS、Miklulicz病有一定的关系。

Purpose To study the diagnostic implication of Sjogren's syndrome's pathological grde and thecorrelation among Sjogren's syndrome, Mikulicz's disease and MALT-ML. Methods ImrnunohistochemistryABC method was used in 6 of 159 cases SS, which were suspected MALT-ML and antibody LCA, UCHL-1,L26, bcl-2, IgA, IgG, IgM, IgD, IgE, κ and λ were included. Results 4 of 6 suspect cases were MALT-MLin which LCA, L26, bcl-2, IgM/κ and IgM/λ were positive expression. Conclusion (1 ) Pathological grade oflower lip, lacrimal gland and salivary gland has important significance in diagnosis SS. (2) MALT-ML is relatedto SS and Mikulicz's disease.