nm23-H1过表达与乳腺癌和皮肤癌转移的相关性

The significance of nm23-H1 overexpression in breast cancer and skin cancer

目的：对比研究乳腺癌与皮肤癌转移抑制基因nm23-H1表达的意义。方法：用单克隆抗体免疫组织化学S-P法检测81例乳腺癌及109例皮肤癌。nm23-H1阳性细胞数超过30％的癌细胞定为过度表达。结果：乳腺癌中导管原位癌、无转移及有转移浸润性导管癌的过表达率分别为82％、77％和33％。皮肤癌中基底细胞癌、无转移及有转移鳞状细胞癌的过表达率分别为79％、61％和27％，差别有显著意义，P＜0005。结论：①nm23H1对皮肤癌和乳腺癌的转移同样有调控功能，但各个不同肿瘤其转移调控所需nm23－H1的数量可能不同.②基底细胞癌与鳞状细胞癌的生物学行为不同，基底细胞癌只浸润不转移，可能与基底细胞癌保留着高水平的nm23－H1有关，其转移行为可能主要由转移抑制基因凋控。

Purpose To compare the significance of nm23-H1 antimetastatic gene overexpression in breastcancer and skin cancer. Methods The expression of nm23-H1 was examined by using monoclonal antibody im-munohistochemical S-P method. Positive cancer cells over 30 % in a case was determined as overexpression. Re-sults In breast intraductal carcinoma, infiltrating ductal carcinoma without and with metastasis, the rates ofnm23-H1 overexpression were 82%, 77% and 33% respectively. In skin hasal cell carcinoma, squamous cellcarcinoma without and with metastasis, the rates of nm23-H1 overexpression were 79 %, 61 % and 27 % respectively. Conclusion The rates of nm23-H1 overexpression have similar features in breast cancers and in skin can-cers and effect on their metastatic control. Basal cell carcinoma is different from squamous cell carcinoma in bio-logic behavior, that is usual infiltration but rare metastasis. We reason out the answer to that hasal cell carcino-ma reserve high level of nm23-H1. Metastatic behavior may be principally controled by the antimetastatic gene.