置管引流胸腔积液联合香菇多糖加顺铂与香菇多糖治疗恶性胸腔积液自身对比研究

Clinical Study of Lentinan Alone or Lentinan Plus Cisplatin Intrathoracic Injection in Patients with Malignant Pleural Effusion

目的:对比胸腔置管引流联合香菇多糖加顺铂与香菇多糖腔内注射治疗恶性胸腔积液的临床疗效差异。方法:选择2009-07～2011-06收治的36例恶性胸腔积液患者,均进行胸腔置管引流后,左侧胸腔先随机注入香菇多糖加顺铂或香菇多糖单药治疗,右侧胸腔则注入另一组药物治疗。1次/周,连续治疗4周,观察并比较两侧胸腔积液的改善情况。结果:顺铂加香菇多糖组总有效率72.22%,香菇多糖组总有效率38.88%,差异有统计学意义(P=0.04)。结论:采用胸腔置管引流联合顺铂加香菇多糖腔内注射治疗恶性胸腔积液可以较好的缓解肿瘤晚期患者的病情,具有积极的临床意义。

Objective：To evaluate the clinical effect of lentinan alone or lentinan plus cisplatin intrathoracic injection in patients with malignant pleural effusion. Methods：36 patients with bilateral malignant pleural effusion were eligible. After indwelling pleural catheters and drainage of pleural effusion, then lentinan plus eisplatin or lentinan was intratho- racic injected in the left side randomly, then the other was intrathoracic injected in the right side. Intrathoracic injection was praticed weekly for 4 weeks. The efficacy and side effects were evaluated weekly. Results： The total effective rates were 72. 22% and 38. 88% （p = O. 04 ）. The toxicities were tolerated. Conclusions： Thoracic tube installation for drainage of pleural effusion and intrathoracic injection of lentinan plus cisplatin for treatment of malignant pleural effusion is safe and effective.