MMP-9在子宫颈鳞状细胞癌中的表达及意义

Expression and Clinical Significance of MMP-9 in Squamous Cell Carcinoma of the Cervix

目的:检测MMP-9在子宫颈鳞状细胞癌中的表达情况,并探讨其与临床病理特征之间的关系。方法:采用免疫组织化学法分别检测MM-9在84例宫颈癌,20例慢性宫颈炎病例中的表达,分析其与临床分期、肿瘤分化程度、淋巴结转移之间的关系。结果:MMP-9在宫颈癌中的阳性表达率为79.8%,显著高于慢性宫颈炎10%(P<0.05)。在高、中、低分化癌中的阳性表达率分别为52.6%、79.5%、100%,其差异具有统计学意义(P<0.05)。在TNMⅠ期组中阳性表达率为58.3%,显著低于TNMⅡ期组95.8%(P<0.05),在淋巴结转移组阳性率为88%显著高于无淋巴结转移组67.6%(P<0.05)。结论:在宫颈癌组织中MMP-9呈高表达,MMP-9可能与宫颈癌的浸润转移有关,对判断宫颈癌患者的预后具有一定意义。

Objective ：To investigate expression and clinical significance of MMP - 9 in squamous cell carcinoma of the cervix, and explore the relationship with clinicopathologic features. Methods：Detecting the protein expression of MMP - 9 in 20 cases of chronic cervicitis and 84 cases of cervical carcinoma by immunohistochemistry and analyzing the relationship between MMP- 9 expression and clinical stages, carcinoma cell differentiation, lymph node metastasis. Results：The positive expression rate of MMP -9 protein in squamous cell carcinoma of the cervix （79. 8% ） was significantly higher than that in chronic cervicitis （ 10. 0% ） （ P 〈 0. 05 ）. The protein expression rate in TNM I （58. 3 % ） was obviously lower than that in TNM II （95.8%）. The protein expression of MMP -9 in lymph node metas- tasis（ 88% ） was higher than that in without lymph node metastasis（67.6% ） （P 〈 0.05 ）. Conclusions： MMP- 9 ex- press higher in squamous cell carcinoma of the cervix, MMP - 9 may be associated with the infiltration and metastasis of cervical carcinoma and can be used for judging the prognosis of the patients with cervical cancer.