γ-干扰素释放试验对活动性肺结核的诊断价值

Diagnostic value of interferon gamma release assay to active pulmonary tuberculosis

目的评价γ-干扰素释放试验(interferon gamma release assay,IGRA)对活动性肺结核的诊断价值。方法采用IGRA检测75例肺结核疑似病例,与结核菌培养结果进行比较。结果 IGRA诊断肺结核灵敏度为81.1%,特异度为90.9%,准确性为84.0%;IGRA灵敏度明显高于结核菌培养(P<0.01);在23例培养阴性的肺结核确诊病例中,16例IGRA阳性。结论 IGRA灵敏度高,特异度强,有助于活动性肺结核的早期、快速诊断。

Objective To evaluate the diagnostic value of interferon gamma release assay to active pulmonary tuberculosis.Methods The interferon gamma release assay based on enzyme linked immunospot assay was performed in 75 patients with suspected active pulmonary tuberculosis.And the result was compared with tuberculosis culture.Results The sensitivity,specificity and accuracy of interferon gamma release assay were 81.1%,90.9% and 84.0%,respectively.The sensitivity of interferon gamma release assay was higher than that of tuberculosis culture（P0.01）.Among 23 cases of negative culture results,16 cases were detected positive by interferon gamma release assay.Conclusion Interferon gamma release assay is highly sensitive,specific and helpful to the early and rapid detection of active pulmonary tuberculosis.