儿童非霍奇金淋巴瘤合并高钙血症1例并文献复习

Non-Hodgkin's lymphoma-associated hypercalcaemia in children:a case report and review of the literature

目的探讨儿童恶性肿瘤相关性高钙血症临床特征,提高对本病的认识及抢救成功率。方法结合1例高钙血症患儿的临床及实验室资料并进行相关文献复习。结果 1例9岁女孩,因原发于腹部的非霍奇金淋巴瘤(成熟B细胞表型)入院,入院后嗜睡、少尿,查血钙5.36 mmol/L,迅速出现肾功能衰竭,经补液、利尿及血液透析等治疗后血钙下降。结论儿童非霍奇金淋巴瘤合并高钙血症罕见,儿科血液专业医师应充分认识本病的危险性及其治疗原则。

Objective To investigate the clinical characteristics of children with malignancy-associated hypercalcaemia and improve its survival rate. Methods Clinical data of 1 case with hypercalcaemia were observed and analyzed. Relevant literature were reviewed. Results A 9-year-old girl was diagnosed with primary abdominal Non-Hodgkin＇ s lymphoma （ mature B ceU phenotype）. She had a high-level serum calcium of 5.36mmol/L, and deteriorated rapidly with renal failure. She got improved after treatment with fluid replacement, diuresis and hemodialysis. Conclusions Non-Hodgkin＇ s lymphoma in children with hypercalcaemia is rare. Pediatric hematologists should pay more attention to the complication and its therapeutic principle.