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人类白细胞抗原Ⅰ类基因多态性与乙型肝炎病毒感染

HUMAn leukocyte antigen cLass I gene polymorphism and hepatitis B virus infection
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摘要 HBV感染人体后的临床表现与机体免疫功能状态密切相关,而人类白细胞抗原(HLA)Ⅰ类基因复合体的表达产物直接调控机体免疫状态,这就造成HBV感染后结局与宿主的HLA基因多态性相互关联。此文主要介绍HLA-Ⅰ基因多态性与乙型肝炎发生发展与预防的关系。 The outcome of HBV infection mainly depends on the host immune response, and human leukocyte antigen (HLA) class I molecules are associated with host immune responses against hepatitis B virus infection. This paper introduces the relationship of HLA- I gene and the prevention, occurrence, development of hepatitis B.
出处 《国际流行病学传染病学杂志》 CAS 2011年第6期396-399,共4页 International Journal of Epidemiology and Infectious Disease
基金 基金项目:国家重大基础研究计划(973)项目(2009CB526411) 高等学校博士学科点专项科研基金(20093420120005)
关键词 肝炎病毒 乙型 人类白细胞抗原 单核苷酸多态性 Hepatitis B virus Human leukocyte antigen SNPs
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