基于炎症反应的应对多种威胁医学救治措施的研究进展

Multi-treat medical countermeasures based on inflammation against chemical agents:research advances

应对多种威胁医学救治措施(multi-threat medical countermeasures,MTMC)是指寻求一组单一药物,使其能够预防、缓解或治疗多种因素引发的人体损伤。近来发现,尽管不同化学战剂作用部位、中毒机制及中毒后的症状表现各异,但是它们都涉及到了共同的信号通道、分子介质及一些细胞过程,这些共同的信号通路可为MTMC研究提供较为明确的作用靶点,其中炎症反应及所参与的炎症介质与受体已成为MTMC研究热点。本文主要就炎症反应与化学中毒救治进行综述。

The multi-threat medical countermeasures （MTMC） have been proposed with the aim at developing a single countermeasure drug which can prevent,relieve and even cure injuries induced by multiple factors. Recently it was shown that although sites and mechanisms of action and symptoms of post-poisoning caused by different chemical insults vary ,they are all in- volved in common biochemical signaling pathways, molecular mediators and cellular processes ,which provide definitive targets for MTMC drugs. Among them, inflammation,as well as inflammatory mediators and their receptors,might be one of the hotspots of MTMC. In this article,inflammation and the countermeasures against chemical agents are reviewed.