胰岛素泵强化治疗对初诊老年2型糖尿病患者胰岛功能的影响

The effect of the continuous insulin pump intensive therapy on islet β-cell function of newly diagnosed elderly type 2 disbetes

目的观察持续胰岛素泵(CSII)强化治疗对初诊老年2型糖尿病的胰岛β细胞功能的影响。方法采用常规2次皮下注射胰岛素类似物诺和锐30(MSII)方法为对照,将初诊老年2型糖尿病患者39例,分为CSII强化治疗组17例,MSII治疗组22例,比较两组治疗前后胰岛β细胞功能、血糖达标天数、平均胰岛素总量及低血糖发生次数等。结果两组治疗后胰岛β细胞功能均明显恢复,但与MSII组相比CSII组改善更为显著(P<0.01),FBG、P2hBG低于MSII组(P<0.05),血糖达标所需时间短于MSII组(P<0.01),平均胰岛素用量少于MSII组(P<0.05),低血糖发生率低于MSII组(P<0.05)。结论对于初诊老年2型糖尿病患者,胰岛素泵强化治疗有利于胰岛素β细胞功能恢复,优于常规2次皮下胰岛素注射治疗。

Objective To observe the effect of the continuous insulin pump（CSII） intensive therapy on islet β-cell function of newly diagnosed elderly type 2 diabetes.Methods 39 patients of newly diagnosed elderly type 2 diabetes were divided into two groups,including of 17 cases that are therapyed by CSII and 22 cases by MCII,islet β-cell function（HOMA-β） 、serum glucose for the average amount of insulin and hypoglycemia frequency of two groups were compared.Results HOMA-β of CSII group were better than MSII group after treatment（P0.01）,P2hBG,FBG of CSII group werelower than MSII group（P0.05）,average time of serum glucose goals was shorter than MCII group（P0.01）,average insulin dosage was fewer than MSII group（P0.05）,the incidence of hypoglycemia was lower than MSII group（P0.05）.Conclusion The continous insulin pump intensive therapy can restore islet β-cell function,which is better than subcutaneous insulin injections for newly diagnosed elderly type 2 diabetes.