TSGF检测的非特异性分析

Analysis of Non-specificity of TSGF Detection

分析恶性肿瘤特异生长因子(TSGF)检测的非特异性.实验分为5组,即健康对照组(579例)、恶性肿瘤组(813例)、感染发热组(326例)、自身免疫性疾病组(283例,红斑狼疮43例、白塞氏病38例、结缔组织病33例、类风湿病58例、多型性红斑32例、脓疱性银屑病26例)、脑梗塞组(318例)、急性脑出血组(52例),空腹取血,测定血清TSGF水平.以TSGF≥71u/mL为阳性,结果发现,TSGF阳性率在感染发热组、恶性肿瘤组、脑梗塞组、自身免疫性疾病组和急性脑出血组分别为92.6%、84.1%、47.8%、41.7%和36.5%.结论:TSGF是早期筛查和辅助诊断恶性肿瘤的良好指标,但在某些非肿瘤性疾病中有较高的非特异性,因此,在临床应用中一定要结合临床表现或其他检测指标进行鉴别.

The study is to analyse the non-specificity of TSGF detection on malignant tumors.The experiment was carried out in five groups.They are healthy people in control group（579 cases）,malignant tumor group（813 cases）,infection with fever group（326 cases）,autoimmune disease group（283 cases,in which 43 infected with lupus erythematosus,38 with Behcet＇s disease,33 with connective tissue disease,58 with rheumatoid disease,32 with polytypism erythema,26 with pustular psoriasis）,cerebral infarction group（318 cases）,acute cerebral hemorrhageroup（52 cases）.The patients＇ blood was collected on an empty stomach and the level of tumor specific growth factor（TSGF） in serum was detected.When TSGF71 u/mL was a positive consult,the positive ratio of TSGF in infection with fever group was 92.6%,that of malignant tumor group,84.1%,that of autoimmune disease group,47.8%,that of cerebral infarction group 41.7% and acute cerebral hemorrhage group was 36.5%,respectively.The conclusion is that TSGF is a good mark in early tumor screening and auxiliary diagnosis,but TSGF has a high non-specificity in some non-tumor diseases,so it must be associated with the patient＇s clinical manifestation and other results to identify the clinical detection.