帕罗西汀联合心理干预治疗脑卒中后抑郁的临床研究

Effect of Paroxetine combined with psychological intervention in the treatment of patients with post-stroke depression

目的观察帕罗西汀联合心理干预治疗脑卒中后抑郁（Post-stroke depression，PSD）的临床疗效。方法随机将脑卒中后抑郁患者分为研究组和对照组，每组各30例，两组均给予帕罗西汀20-40mg每天早晨服用；研究组同时予以每周3次心理干预。治疗前和治疗后分别用汉密尔顿抑郁量表（Hamilton depression scale，HAMD）、脑卒中患者临床神经功能缺损程度评分标准（1995）评定疗效。结果治疗8周后，研究组的抑郁治疗效果和神经功能缺损治疗效果的总有效率分别为86．67％和76．67％，对照组分别为53．33％和43．33％，研究组优于对照组（P〈0．05），两组间差异有统计学意义。结论帕罗西汀联合心理干预治疗有良好的抗抑郁及促进神经功能恢复的作用，疗效优于单用帕罗西汀治疗。

Objective To observe the effect of Paroxetine combined with psychological intervention for treating post-stroke depression. Methods Sixty patients with post-stroke depression （PSD） were divided into the study group and the control group, each with 30 cases. Patients in the two groups were treated with 20-40 mg paroxetine every morning. Those in the study group were additionally treated with psychological intervention three times a week. The therapeutic efficacy was evaluated through Hamilton depression scale （HAMD） and Stroke patients with neurological impairment score standard （1995） before treatment and aider treatment. Results Eight weeks after treatment, the total effective rates of the treatment of depression and neurological impairment were 86.67% and 76.67% in the study group which were significantly higher than those in the control group （53.33% and 43.33%, respectively）. Conclusion Paroxetine combined with psychological intervention can significantly improve anti-depression and recovery degree of neurological impairment, which results in better therapeutic efficacy than paroxetine alone.