山西长治地区健康林州移民及食管鳞癌患者血浆核黄素水平的比较及其意义

A comparison and significance of plasma riboflavin levels in patients with esophageal squamous cell carcinoma versus Linzhou healthy migrants in Changzhi of Shanxi

目的 探讨核黄素缺乏与食管鳞癌发生的关系.方法 采用ELISA法检测山西长治地区食管鳞癌患者（445例）、长治当地健康人群（689例）及健康林州移民（347例）3组人群的血浆中核黄素水平并比较其差异.结果 长治地区食管鳞癌患者[ （731.69 ±330.67） μg/L]血浆中核黄素水平显著低于长治当地健康人群[（1090.43±445.08） μg/L]和健康林州移民[（897.58±177.78）μg/L],P值均＜0.05；而长治当地健康人群血浆中核黄素水平高于健康林州移民,P＜0.05.结论 在食管鳞癌患者中存在核黄素缺乏现象,长治本地健康人群血浆中核黄素水平高于健康林州移民,具体机制有待于进一步研究.

Objective To study the relationship between plasma riboflavin levels and esophageal squamous cell carcinoma.Methods We detected and compared plasma concentrations of riboflavin in patients with esophageal squamous cell carcinoma （ESCC） and immigrants of Linzhou living in Changzhi.Plasma riboflavin levels were quantified in 445 ESCC patients,689 healthy control subjects and 347 immigrants of Linzhou living in Changzhi by using enzyme-linked immunosorbent assay.Results The plasma riboflavin levels in patients with ESCC were significantly lower than those in the healthy controls and immigrants of Linzhou living in Changzhi [ （731.69 ± 330.67 ） μg/L vs （ 1090.43 ± 445.08 ） μg/L,（731.69 ± 330.67） μg/L vs （ 897.58 ± 177.78） μg/L,respectively,all P 〈 0.05 ],and the plasma riboflavin levels of the healthy controls were higher than those in the immigrants of Linzhou living in Changzhi （P 〈 0.05）.Conclusion Patients with ESCC have decreased plasma riboflavin levels as compared with the healthy controls and immigrants of Linzhou living in Changzhi,there exists a lack of riboflavin in ESCC patients,but the specific mechanism needs further study.