福善美结合钙尔奇D治疗绝经后骨质疏松的疗效观察

Observation on Clinical Healing Effect of Fosamax Combining Callrate D for Treating Female Postmenopausal Osteoporosis

目的探讨福善美与钙尔奇D联合治疗绝经后骨质疏松症（PMO）的临床疗效。方法156例绝经后骨质疏松患者随机分为治疗组87例和对照组69例，治疗组接受福善美、钙尔奇D联合治疗；对照组仅口服钙片治疗，均经1年的治疗。观察两组治疗前后VRS疼痛评分、血钙、血磷和碱性磷酸酶变化情况，双能X线吸收仪（DEXA）测量两组治疗前后腰椎（kq）前后位密度（BMD）的变化情况，并进行统计学分析。结果治疗组和对照组治疗前后骨密度BMD分别为0．876＋0157、0．947±0．203和0．879±0149、0.881±0.161，治疗组治疗前后骨密度BMD变化有显著差异（P〈0．05）。对照组无显著差异（P〉0．05）；两组治疗后的骨密度BMD有显著差异（P〈0．05）。治疗组骨痛VAS评分总改善效率明显高于对照组（P〈0．05）。两组血钙、血磷和对照组碱性磷酸酶治疗前后无明显改变（P〉0.05），但治疗组碱性磷酸酶较治疗前明显下降（P〈0.05）。结论福善美与钙尔奇D联合治疗绝经后骨质疏松能显著改善骨痛并提高骨密度。

Objective To observe the herapeulie effects of alendronate（Fosamax） combining Callrate D for treating femal postmenopausal osteoporosis. Methods 156 cases of postmenopausal steoporosis patients were randomized into the treatment group（87 cases） and the control group（69 cases）, the treatment groups taking Fosamax, Callrate D, and at the same time, the control group taking Callrate D only. After one year＇s treatment, to observe the VRS bone pain score, serum calcium, serum phosphate, alkaline phosphatase （ALP）. The BMD at the lumbar spine （L-~4） measured by dula energy X-ary absorptiometry, before and after treatment of the two groups. Result The bone mineral density before and after treatment bewteen the treatment group and＇controlr group were 0.876±0.157, 0.947±0.203 and 0.879±0.149, 0.881±0.161, before and after treatmnt of the treatment goup, the bone mineral density were significantly different（P〈0.05） while the control group showed no significant diference（P〉0.05）. The treatment group VRS bone pain evaluation obviously superior the control group（P〈0.05）. The serum calcium, serum phosphate, alkaline phosphatase（ALP） before and after treatment of the two groups showed no significant diference （P〉0.05）. The alkaline phosphatase （ALP） after treatment bewteen the treatment group and controlr group were decreated differentily （P〈0.05）. Conclusion Fosamax combining Callrate D for treating femal postmenopausal osteoporosis can signiifcantly reduce the pain and increase the lumbar verlebra BMD.