波依定治疗原发性高血压的疗效观察

Efficacy of Plendil in Treatment of Essential Hypertension

目的探讨波依定治疗原发性高血压的疗效及副作用。方法选择80例原发性高血压患者，按就诊先后顺序随机分为观察组和对照组，每组40例。观幂蛆口服波依定5-10mg／d．对照组口服硝苯地平缓释片20-40mg／d，疗程均为4周，观察比较两组的临床疗效厦副反应。结果观察组的总有效率94．8％，对照组的总有效率81．6％，组间具有显著性差异（P〈0．05）；观察组不良反应率14．5％，对照蛆不良反应率41．6％，两组之间差异具有显著性（P〈0．05）。结论波依定治疗原发性高血压具有高效、剂量小、安全、患者依从性好等优点，可作为抗高血压的一线用药。

Objective To explore the clinical effficacy and adverse reactions of plendil in the treatment of essential hypertension. Methods According to treatment order, 80 cases with essential hypertension, have been divided into observation group and control group, n=40. Observation group was was treated with oral plendil 5-10mg/d; control group was treated with oral nifedipine 20-40mg/d. The treatment time were continued for 4 weeks. The clinical effficacy and adverse reactions were observed and compared between the two groups. Results The total efficiency of observation group was 94.8% and control group 81.6%. Efficacy between the two groups was significant difference （P〈0.05）. The adverse events of observation group was 14.5% and control group 41.6%. Adverse events was significant difference between the two groups （P〈 0.05）. Conclusion Plendil has advantages with high efficiency, small doses, safety, good patient compliance in treatment of primary high earth pressure, can be used as first-line anti-hypertenslve medication.