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强光源致大鼠视网膜光损伤中的C-JUN

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摘要 目的测定强光源致大鼠视网膜光损伤中的c-jun的表达,探索C-Jun作为活化的AP-1成员在感光细胞凋亡过程中的作用。方法24只SD大鼠随机分为空白对照组、模型对照组。采用YZ20T眼科手术显微镜,距角膜距离为150+3mm照射右眼,照射时间为30min,照度为22000+1000Lux。光照后暗适应24小时。取眼球进行视网膜免疫组化检查,测定c-jun的表达。结果模型组c-jun表迭与空白组之间差异无统计学意义。结论光性感光细胞凋亡过程中可能并不需要由N端磷酸化的c-jun/AP-1导致的靶基因转录激活。
出处 《医学信息》 2011年第23期774-774,共1页 Journal of Medical Information
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