家族聚集性高血压MAPK信号通路基因表达研究

MAPK signal pathway genes expression in patients with familial aggregated hypertension

目的:检测家族聚集性高血压患者MAPK信号通路基因表达,以明确该通路是否参与家族聚集性高血压的形成。方法:选择3代以上直系亲属均有高血压病史的5例患者作为试验组,对照组为5例健康志愿者;采用实时定量PCR芯片检测外周血液MAPK信号通路功能分类基因的表达。结果:试验组与对照组相比,MAPK信号通路功能分类基因表达>2.0倍的基因共有55个,≤0.5倍的基因1个。结论:MAPK信号通路在家族聚集性高血压的发病中起着重要作用,并涉及广泛的功能分类基因。

Objective：To detect the gene expression profiling of the MAPK signal pathway in familial aggregated hypertension patients by real-time PCR gene array and screen differently expressed genes.To identify if the MAPK signal pathway involved in the formation of the familial aggregated hypertension.Method：We selected 5 patients with more than three generations lineal relatives suffering from hypertension as group,and 5 healthy persous as control group.Real-time PCR gene array detected the expression of peripheral blood MAPK signal pathway functional classification genes.Result：Compared with the control group,there were 56 differently expressed genes in hypertension group.Expression of 55 genes increased to more than two times and 1 decreased to below 0.5 times.Conclusion：This study suggested the MAPK signal pathway related to the initiation and development of the familial aggregated hypertension,and involved in broad functional classification genes.