移植物抗宿主病和移植物抗白血病效应的发生机制及分离策略的研究进展

Advance in mechanisms and strategies of separation between graft-versus-host disease and graft-versus-leukemia effect

异基因造血干细胞移植（allogeneic hematopoietic stem cell transplantation,allo-HSCT）为恶性疾病提供了一种全新的治疗策略并广泛应用于恶性疾病的治疗。通过移植治疗,其移植物抗白血病（graft-versus-leukemia,GVL）效应对恶性疾病的治疗及防止移植后疾病复发发挥着关键作用,

Graft-versus-host disease（GVHD） is an important factor and has significant influence on survival after allogeneic hematopoietic stem cell transplantation（allo-HSCT）.Graft-versus-leukemia（GVL） effect is a key factor that affects the treatment and recurrence after allo-HSCT.In order to increase the validity and safety on allo-HSCT in clinical application,the detailed mechanisms of GVHD and GVL are investigated,and the separation of GVL from GVHD in allo-HSCT,including early prediction and diagnosis of GVHD,modification of donor graft cells and drug intervention,is extensively studied.