细胞自噬及其与肿瘤关系的研究进展

Progress in Studies on the Relationship between Autophagy and Cancer

细胞自噬是一种细胞自我降解的过程,在适应代谢应激、保护基因组完整性及维持内环境稳定方面起到重要作用。在许多人类肿瘤中存在自噬水平的改变。肿瘤发生发展的不同阶段,自噬起到了促进和抑制的双重作用。该文综述了细胞自噬的分子机制及其与肿瘤关系的主要研究进展。

Autophagy, a cellular self-degradation process, is crucial for metabolic stress, genomic integrity and cellular homeostasis. The levels of autophagic activity are different in diverse tumors. Autophagy plays important roles at different stages of tumorigenesis and cancer progression. In this review, we discussed the molecular mechanisms of autophagy and the implication of autophagy in human cancer.