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新型人类逆转录病毒XMRV研究进展

Research Progress in Xenotropic Murine Leukemia Virus-Related Virus——A New Human Retrovirus
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摘要 异嗜性鼠白血病病毒相关病毒(xenotropic murine leukemia virus-related virus,XMRV)是迄今发现的第一种可以感染人类的r逆转录病毒。XMRV最初于2006年在RNase L基因缺陷型的前列腺癌组织中首次被鉴定,其序列与鼠科白血病病毒(murine leukemia virus,MLV)十分相似。目前,北美、欧洲和亚洲的多个研究机构在人类前列腺癌和慢性疲劳综合征(chronic fatigue syndrome,CFS)患者中检测到XMRV。但不同研究间结果差异很大,XMRV感染与人类疾病之间的相关性尚不明确。该文综述了目前XMRV的相关研究进展,包括与人类疾病的关系、XMRV的基本特征、病理生理学可能的机制等方面,并就今后研究趋势和注意问题进行了讨论。 Xenotropic murine leukemia virus-related virus （XMRV） is a new gammaretrovirus that can infect humans. Retroviruses are enveloped, positive-sense RNA viruses that are associated with many diseases, such as neoplasias, immunodeficiencies, and neurological disorders. XMRV was originally identified in prostate cancer patients with a deficiency in the antiviral enzyme RNase L in 2006. The genome of XMRV is closely related to xenotropic murine leukemia virus （MLV）. Recently, several independent groups have detected XMRV in prostate cancer and chronic fatigue syndrome patients, but the results vary greatly. The link between XMRV and human diseases has not been established. This paper presents and summarizes in detail the characteristics of XMRV, asso- ciation of XMRV with human diseases, and potential mechanisms of XMRV pathophysiology. We also discuss the future research direction, such as the establishment of standard operation procedure and epidemiologic evidence of an association of XMRV with human diseases in large-scale studies.
作者 王斌 沈肖曹 张哲 邓刚 王丹 叶剑 沈学彬 苏锟楷 陈欢 杨军 张苏展 Samson A Chow
机构地区 浙江大学浙江加州国际纳米技术研究院 浙江大学医学院附属第二医院 宁波市中心血站 浙江省微生物研究所 加州大学洛杉矶分校医学院分子药理学系分子生物学研究所和UCLA艾滋病研究所
出处 《中国细胞生物学学报》 CAS CSCD 2011年第12期1374-1385,共12页 Chinese Journal of Cell Biology
基金 浙江省教育厅科研计划(No.Y201016208) 宁波市社会发展科研项目(No.2010C50027)资助项目~~
关键词 异嗜性鼠白血病病毒相关病毒(XMRV) γ逆转录病毒 RNASE L 前列腺癌 慢性疲劳综合征(CFS) 致病机制 xenotropic murine leukemia virus-related virus （XMRV） gammaretrovirus RNase L prostate cancer chronic fatigue syndrome pathophysiology
分类号 R373 [医药卫生—病原生物学]
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参考文献83

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中国细胞生物学学报
2011年 第12期

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