酒精对实验性糖尿病大鼠血瘀状态的影响

Effects of Alcohol on SD Diabetic Rats with Blood Stasis

目的:研究探讨不同剂量酒精对实验性糖尿病大鼠血瘀状态的影响。方法:采用链脲佐菌素制成糖尿病大鼠模型,将其随机分为糖尿病对照组、少量饮酒组和大量饮酒组,并设正常对照组。观察大鼠一般状态,30天后拍摄舌象,分析比较舌质色泽的深浅及舌下脉络的长短迂曲程度,并对4组大鼠采血测血流变、血糖并进行分析。结果:①糖尿病3组血瘀比例显著高于正常对照组(P<0.01);少量饮酒组舌下脉络血瘀比例显著低于大量饮酒组及糖尿病对照组(P<0.01)。②糖尿病3组血流变较正常对照组明显升高;少量饮酒组的全血高切显著低于糖尿病对照组及大量饮酒组(P<0.01);大量饮酒组的血流变学各项指标(除红细胞压积外)均显著高于糖尿病对照组及少量饮酒组(P<0.05)。结论:少量饮酒能改善红细胞变形性从而有助于改善糖尿病大鼠的血瘀状态。

Objective： To investigate the effect of alcohol consumption on diabetic rats model of blood stasis syndrome. Methods ： All 36 SD rats were randomly divided into 4 groups ： the blank group, the non - drinking group, the moderate drinking group and the excessive drinking group. The general state of rats were observed for 30 days. Later, the tongue pictures of all rats were taken with digital camera, and then the color and luster changes of tongue ventral surface and the coloration length of sublingnal vein were compared, and four groups of rats were measured and analyzed about blood rheology, blood glucose. Results ：（1）The proportion of three diabetic groups of blood stasis was significantly higher than that of the blank group（ P 〈 0. 01 ） ; the sublingual vein blood stasis proportion of the moderate drinking group was significantly lower than the excessive drinking group and the non -drinking group（ P 〈0.01 ）. （2）Three groups diabetic changes in blood rheology was significantly higher than that of the blank group ; whole blood high - shear of the moderate drinking group was significantly lower than that of the non - drinking group and the excessive drinking group （ P 〈 0.01 ） ; blood rheology of each indicator （ except hematocrit） of the excessive drinking group was significantly higher than that of the blank group and the moderate drinking group（ P 〈0.05）. Conclusion ：The moderate drinking style had improved red blood cells＇deformabfility,so it could help improve the state of blood stasis in diabetic rats.