人羊膜间充质干细胞的生物学特性及临床前研究

Biological Properties and Preclinical Studies of Human Amniotic Mesenchymal Stem Cells

近年来随着对间充质干细胞功能特性的深入研究,间充质干细胞已经成为细胞替代治疗的研究热点。而人羊膜间充质干细胞(human amniotic mesenchymal stem cell,hAMSC),除与时下研究热、应用广的骨髓间充质干细胞(Bone marrow mesenchymal stem cell,BM-MSC)一样具有多向分化潜能、免疫调节、造血支持等特性外,还具有来源广泛、取材方便、无伦理限制、细胞增殖能力强等优势。多项研究还证明,hAMSC移植免疫排斥少,成功率高,在各种组织器官中存活率高,存活时间长。以上诸多优势,使得其在细胞替代治疗和再生医学研究领域备受关注。

Mesenchymal stem cells have been the topic of cell-replaced therapy in recent years. There are similar functional features in hAMSC and BM-MSC, such as low immunogenicity, immunoregulation, muhilineage differentiation capacity and hematopoietic support. In addition, hAMSC has several special advantages, such as relatively easy isolation and purification, better proliferation, more resourses and no ethical disputes. The ability of hAMSC to successfully engraft and survive long-term in various organs and tissues, makes sure its significant impact in the fields of cell-replaced therapy and regenerative medicine.