肝动脉热灌注治疗中晚期肝癌的疗效观察

The curative effect observation of hepatic artery thermal perfusion used in treatment of middle-late stage HCC

目的探讨经肝动脉热灌注化疗栓塞术治疗中晚期肝癌的疗效。方法 186例中晚期肝癌患者,分成两组,加热组93例,行大剂量加热碘油及热化疗药物灌注治疗;常规组93例按常温下化疗药物和碘油栓塞治疗;进行治疗前后肿瘤大小、生存率、肝功能损伤的对比分析。结果两组治疗前后肝内肿瘤大小变化的比较有统计学差异(P<0.05),随访6、12、18、24个月的生存率,加热组生存率分别为97.85%(91/93)、88.17%(82/93)、73.12%(68/93)、46.24%(43/93);常规组生存率分别为87.10%(81/93)、76.34%(71/93)、46.23%(43/93)、22.58%(21/93);两组生存率比较有统计学差异(P<0.05)。结论经肝动脉热灌注化疗栓塞术治疗中晚期肝癌临床疗效优于常规方法,且并发症少。

Objective To evaluate the curative effect of hepatic artery hot perfusion used in treatment of middle-late stage hepato-cellular carcinoma （HCC）. Methods 186 cases hepatocellular carcinoma patients in middle-late stage were divided into two groups, 93 cases in heating group were treated with large doses of thermal lipiodol and thermal chemotherapy drugs ; patients in nor- mal group were treated by chemotherapy drugs and lipiodol embolization under the normal temperature; the size change of liver tumor, survival rate and liver function before and after the treatment were compared and analyzed. Results Before and after the treatment of the 2 groups, statistic differences were showed after the comparation of size change of liver tumor （ P 〈 0.05 ）, the survival rate of 6,12,18,24 months were followed up, the survival rate of heating group were 97.85% （91/93） ,88.17% （ 82/93）, 73.12% （68/93） and 46.24 （43/93） respectively; in normal group, the survival were 87.10% （81/93）, 76.34% （71/93）, 46.23 % （43/93） and 22.58 % （21/93 ） respectively; it has statistic differences after comparing the suvival rate of 2 groups （P 〈 0.05 ）. Conclusion The clinical effect of hepatic artery thermal peffusion embolization used in treatment of middle-late stage HCC was superior than normal methods, and with fewer complications.