CD3+CD28+T细胞与晚期非小细胞肺癌化疗疗效的相关性研究

A study of correlation between CD3^+CD28^+T cell value and chemotherapy in patients with advanced non-small cell lung cancer

目的探讨CD3+CD28+T细胞与晚期非小细胞肺癌化疗疗效的相关性。方法 40例有可测量病灶的晚期非小细胞肺癌患者接受NP方案化疗,化疗前采用流式细胞术检测外周血CD3+CD28+T细胞的数值,进行有效组(CR+PR)、稳定组(SD)、进展组(PD)和正常对照组四组间比较,并进行疗效与CD3+CD28+T细胞值的相关性分析。结果化疗前有效组的CD3+CD28+T细胞值与对照组相比差异无统计学意义(P=0.158),稳定组和进展组均低于对照组(P=0.003,P=0.000);有效组明显高于稳定组和进展组(P=0.036,P=0.000),稳定组高于进展组(P=0.000)。疗效与CD3+CD28+T细胞数值的相关系数r=0.672(P=0.000)。结论化疗前CD3+CD28+T细胞检测值与化疗疗效有一定的相关性,化疗前CD3+CD28+T细胞数值高,则化疗效果好。

Objective To explore the correlation between CD3 ＋ CD28 ＋ T cell value and chemotherapy in patients with advanced non-small cell lung cancer （NSCLC）. Methods By flow cytometry, the absolute counts of CD3 ＋ CD28 ＋ T cells in peripheral blood from 40 patients with advanced NSCLC were detected before chemotherapy. All the patients with measurable tumor accepted NP Chemotherapy. The chemotherapeutic efficacy was determined in four groups ： complete response plus partial response （ CR ＋ PR）, stable disease（SD） and progressive disease （PD） and control. Make comparison studies among CR ＋ PR, SD, PD and control group. Study therapeutic effect related to the value of CD3 ＋ CD28 ＋ T cell. Results There was no statistical significance in difference in value of CD3 ＋ CD28 ＋ T cell between CR ＋ PR group and control group before chemotherapy （ P = 0. 158 ）, the value of CD3 ＋ CD28 ＋ T cell in SD group and PD group were lower than that in control group （ P = 0.003, P = 0. 000）. CD3 ＋ CD28 ＋ T cell value in CR ＋ PR group was higher than that in SD group and PD group （ P = 0.036, P = 0.000）, while in SD group was higher than in PD group （ P = 0.000）. Correlation coefficient between efficacy and CD3 ＋ CD28 ＋ T cell was 0. 672 （ r = 0. 672, P = 0. 000）. Conclusion There was the relationship between effect of chemotherapy and CD3 ＋ CD28 ＋ T cell value, before chemotherapy there is better therapeutic effect ff the value of CD3 ＋ CD28 ＋ T cell is near to that in healthy persons.