摘要
以滇池蓝藻为载体,利用其抗紫外特性,用卡波姆树脂包裹蓝藻?阿维菌素(Avermectin,Av)粉,制成阿维菌素抗紫外缓释剂,利用FT-IR,SEM和HPLC等对蓝藻和缓释剂进行表征,研究其吸附与释放行为.结果表明,Av在异丙醇中的饱和吸附量为160.81mg/g,包裹10%卡波姆树脂的抗紫外缓释剂具有很好的缓释功能,在乙醇/水(4:1,φ)中释放20d,累计释放率为51.8%,释放机制是Fick扩散和骨架溶蚀的双重机制.经4h紫外光照射,含蓝藻的制剂中Av残留量为61%,不含蓝藻的制剂中Av残留量为39%.
A major objective of the present work is to develop anti-UV controlled release formulation of avermectin(Av),with utilizing the anti-UV characteristic of blue algae as carrier taken from Dianchi Lake.Av was adsorbed on blue algae powder and then coated with 10% carbomer resin.The blue algae powder and release formulation were characterized by FT-IR,SEM and HPLC.The results show that the adsorptive capacity of Av is 160.81 mg/g in isopropanol at 25℃.The formulation release rate is 51.8% for 20 d in ethanol/water(4:1,j) at 25℃.The controlled release mechanism belongs to Fickian diffusion and matrix erosion.The residual rates of Av with blue algae and alone are 61.0% and 39.0% respectively under UV irradiating.It is improved that blue algae has the function of resistance against UV.
出处
《过程工程学报》
CAS
CSCD
北大核心
2011年第5期846-850,共5页
The Chinese Journal of Process Engineering
基金
国家自然科学基金资助项目(编号:20872093)
国家高技术研究发展计划(863)基金资助项目(编号:2011AA100503)
国家十二五科技支撑计划基金资助项目(编号:2011BAE06B06)
上海市教委资助项目(编号:11ZZ122)
上海市重点学科基金资助项目(编号:S30406)
关键词
蓝藻
阿维菌素
抗紫外缓释剂
blue algae
avermactin
adsorption
anti-UV controlled release formulation