瘦素(Leptin)与体力活动的研究综述

A Review of Leptin in Physical Exercise

L eptin是 ob基因表达的脂肪组织源激素 ,其主要作用是减少体脂、控制体重和调节机体能量平衡。它的产生和代谢受到遗传和体内外环境因素的调控和影响。运动训练可减低 ob m RNA的表达和血 leptin浓度 ,训练所致的体脂量下降是产生这种作用的重要决定因素。单次运动对 lepin表达和其血中浓度的效应 ,有减低与无影响的研究结果。运动的这些效应可能依赖于运动负荷量和热能消耗量 ,也与一些激素和代谢物有关。

As a protein product of ob gene, leptin is an adipocyte derived hormone that has been shown to reduce body fat content, control bodyweight and regulate energy balance. The production and metabolism of leptin are modulated by the genetic and environmental factors. Physical exercise can decrease ob mRNA expression and plasma leptin concentration, of which the exercise induced reduction in body fat content is a major determinant. There has been a decreased effect or no meaningful influence of an acute bout of exercise on ob gene expression and serum leptin levels in different studies. The effects of physical exercises on leptin may be dependent upon work loads and energy expenditure, and may also be related to some hormones and metabolites.