麝香保心丸对高血压合并房颤患者内皮功能的影响

Efect of Shexiang Baoxin Wan on blood vessel endothelial function in patients with atrial fibrillation complicated with hypertension

目的探讨麝香保心丸对原发性高血压合并房颤患者血管内皮功能的影响。方法采用随机、对照、单盲法,选取原发性高血压合并房颤患者36例,分为麝香保心丸治疗组和常规治疗组各18例。麝香保心丸组除高血压常规治疗外,加用麝香保心丸2丸,3次.d-1,口服;常规治疗组仅给予常规降压治疗。疗程均为60d。治疗前后分别进行肱动脉血流介导性舒张功能(FMD)超声检测。选取原发性高血压无房颤者为对照组,共18例。结果与无合并症的高血压患者相比,高血压合并房颤者内皮功能受损。麝香保心丸组与常规治疗组比较,反应性充血时内径舒张百分比差异无统计学意义(P>0.05);疗程结束时麝香保心丸组肱动脉反应性充血时内径舒张百分比显著高于常规治疗组(P<0.05)。结论原发性高血压合并房颤患者血流介导性舒张功能减退,麝香保心丸能明显改善血流介导性舒张功能,说明在降压基础上加用麝香保心丸可以改善高血压合并房颤患者的内皮功能。

Objective To determine the efect of Shexiang Baoxin Wan on blood vessel endothelial function in patients with atrial fibrillation complicated with hypertension.Methods Thirty-six patients with atrial fibrillation complicated with essential hypertension were enrolled.The patients were randomly divided into a Shexiang Baoxin Wan group（n=18）and a routine group（n=18）,who were treated for 60 d.The Shexiang Baoxin Wan group was treated with Shexiang Baoxin Wan,2 pills each time and 3 times a day;while the routine group were treated routinely.Brachial vascular ultrasound was carried out for flow-mediated dilation before and after the treatment.Eighteen patients with essential hypertension only were enrolled as a control group.Results Diastolic percentage of internal diameter during reactive hyperemia was lower in the 2 treatment groups than that in the control group before the treatment（P0.05）,but there was no significant difference between the Shexiang Baoxin Wan group and the routine group.Diastolic percentage of internal diameter in Shexiang Baoxin Wan group was significantly higher than that in the routine group（P0.05）.Conclusion Flow-mediated dilation of the patients with atrial fibrillation complicated with hypertension is degrading,but it is improved by Shexiang Baoxin Wan treatment,indicating that abnormal endothelial function is improved better in the Shexiang Baoxin Wan group than in the routine group.