美托洛尔合用依那普利对新发青年高血压的疗效

Evaluation the effect of metoprolol tartrate tablets combine enalapril maleate tablets on the treatment of newly-onset young essential hypertension

目的 利用动态血压检测评价酒石酸美托洛尔合用马来酸依那普利治疗青年新发高血压的疗效.方法 78例入选患者服用酒石酸美托洛尔12.5 mg,每日2次,马来酸依那普利5 mg,每日1次,并逐渐加量至诊室血压达标或最大量美托洛尔150 mg/d、马来酸依那普利20 mg/d,服用3周.治疗前、后进行动态血压检测.结果 治疗前24 h平均SBP为（162.4±9.8）mm Hg,DBP为（94.2±7.5）mm Hg,治疗后SBP为（128.3±5.8）mm Hg,DBP为（73.2±6.1）mm Hg,均显著降低（P＜0.01）,夜间血压下降率明显增加（P＜0.01）,总有效率97.43%.结论 对新发青年高血压,酒石酸美托洛尔联合马来酸依那普利能达到24 h平稳降压.

Objective Evalution the effect of metoprolol tartrate tablets combine enalapril maleate tablets on the treatment of newly-onset young essential hypertension by using ABPM technology. Methods 778 selected patients were given with metoprolol tartrate of 12.5 mg twice a day and enalapril maleate of 5 mg once a day and the dosage was gradually increased until reaching the target office blood pressure or metoprolol in the maximum dosage of 150 mg and Enalapril maleate of 20 mg once a day. Medication lasted for 3 weeks. Ambulatory blood pressure test was taken before and after treatment. Results The 24 h meanbloodpressure before treatment： SBP （ 162.4±9.8）mm Hg, DBP（94.2±7.5）mm Hg, after treatment：SBP（128.3±5.8）mm Hg, DBP （73.2±6.1）mm Hg. 24 h Ambulatory blood pressure was obviously declined after treatment （P〈0.01）. Nighttime blood pressure decrease rate significantly increased （P〈0.01）. The total effective rate was 97.43%. Conclusion Steady blood pressure decline for 24 hours can be achieved by medication of metoprolol tartrate combined with enalapril maleate for young patients who has newly onset essential hypertension.