摘要
目的:探讨动态脉压及其指数与高血压患者颈动脉内膜-中层厚度(IMT)的关系。方法:测量159例研究对象的24h动态血压,并计算动态脉压(平均收缩压-平均舒张压)及动态脉压指数(动态脉压/平均收缩压)。使用彩色多普勒超声检测颈动脉IMT。分析动态脉压指数与颈动脉IMT的相关性。结果:Pearson相关分析发现,颈动脉IMT与年龄(r=0.353)、平均收缩压(r=0.594)、平均舒张压(r=-0.355)、动态脉压(r=0.855)、动态脉压指数(r=0.883)有良好的相关性(P均<0.001)。进一步行多元逐步回归分析显示,颈动脉IMT与动态脉压及动态脉压指数具有显著线性关系(R2=0.789),动态脉压指数的标准回归系数(β=0.621)大于动态脉压的(β=0.284)。结论:动态脉压指数和动态脉压是评价颈动脉血管硬化的良好指标,动态脉压指数的价值更大。
Objective: To study relationship among ambulatory pulse pressure (PP), pulse pressure index (PPI) and carotid intima--media thickness (IMT) in aged patients with hypertension. Methods: The 24h ambulatory blood pressures of 159 subjects were measured, and their ambulatory PP E(mean systolic blood pressure (SBP) mean diastolic blood pressure (DBP)] and ambulatory PPI (ambulatory PP/mean SBP) were calculated. Color Doppler ultra- sonography was used to measure carotid IMT. Relationship between ambulatory PPI and carotid IMT was analyzed. Results: Pearson correlation analysis indicated that carotid IMT was correlated with age (r=0. 353), mean SBP (r- 0.594), mean DBP (r=--0.355), ambulatory PP (r 0.855) and ambulatory PPI (r=0.883), P〈0.001 all. Multivariant gradual regressive analysis indicated that carotid IMT possessed significant linear correlation with ambulatory PP and ambulatory PPI (R2 =0. 789), and standardized regression coefficient t3 of ambulatory PPI (β=0. 621) was higher than that of ambulatory PP (β= 0. 284) . Conclusion: Ambulatory pulse pressure index and ambulatory pulse pressure are good indicators for evaluation of carotid arteriosclerosis, and value of ambulatory pulse pressure index is more than.
出处
《心血管康复医学杂志》
CAS
2011年第6期504-507,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
高血压
血压监测
便携式
颈动脉
动脉硬化
Hypertension
Blood pressure monitoring, Ambulatory
Carotid arteries
Arteriosclerosis