老年高血压患者动态脉压和脉压指数与颈动脉内膜-中层厚度的关系(英文)

Relationship among ambulatory pulse pressure,pulse pressure index and carotid intima-media thickness in aged patients with hypertension

目的:探讨动态脉压及其指数与高血压患者颈动脉内膜-中层厚度(IMT)的关系。方法:测量159例研究对象的24h动态血压,并计算动态脉压(平均收缩压-平均舒张压)及动态脉压指数(动态脉压/平均收缩压)。使用彩色多普勒超声检测颈动脉IMT。分析动态脉压指数与颈动脉IMT的相关性。结果:Pearson相关分析发现,颈动脉IMT与年龄(r=0.353)、平均收缩压(r=0.594)、平均舒张压(r=-0.355)、动态脉压(r=0.855)、动态脉压指数(r=0.883)有良好的相关性(P均<0.001)。进一步行多元逐步回归分析显示,颈动脉IMT与动态脉压及动态脉压指数具有显著线性关系(R2=0.789),动态脉压指数的标准回归系数(β=0.621)大于动态脉压的(β=0.284)。结论:动态脉压指数和动态脉压是评价颈动脉血管硬化的良好指标,动态脉压指数的价值更大。

Objective： To study relationship among ambulatory pulse pressure （PP）, pulse pressure index （PPI） and carotid intima--media thickness （IMT） in aged patients with hypertension. Methods： The 24h ambulatory blood pressures of 159 subjects were measured, and their ambulatory PP E（mean systolic blood pressure （SBP） mean diastolic blood pressure （DBP）] and ambulatory PPI （ambulatory PP/mean SBP） were calculated. Color Doppler ultra- sonography was used to measure carotid IMT. Relationship between ambulatory PPI and carotid IMT was analyzed. Results： Pearson correlation analysis indicated that carotid IMT was correlated with age （r=0. 353）, mean SBP （r- 0.594）, mean DBP （r=--0.355）, ambulatory PP （r 0.855） and ambulatory PPI （r=0.883）, P〈0.001 all. Multivariant gradual regressive analysis indicated that carotid IMT possessed significant linear correlation with ambulatory PP and ambulatory PPI （R2 =0. 789）, and standardized regression coefficient t3 of ambulatory PPI （β=0. 621） was higher than that of ambulatory PP （β= 0. 284） . Conclusion： Ambulatory pulse pressure index and ambulatory pulse pressure are good indicators for evaluation of carotid arteriosclerosis, and value of ambulatory pulse pressure index is more than.