奥拉西坦改善脑梗死患者认知功能的疗效

Effects of oxiracetam on improvement of cognition in patients with cerebral infarction

目的:评价奥拉西坦改善脑梗死患者认知功能的临床疗效。方法:入选脑梗塞患者96例,随机分为奥拉西坦组(采用奥拉西坦为主的治疗方案)和常规治疗对照组(采用常规治疗),各48例。运用简易精神状态量表(MMSE)和巴氏指数(BI)测定治疗前后两组患者的分值,并进行比较分析。结果:治疗一个月后,两组MMSE、BI分值均较治疗前有明显提高(P<0.05～0.01),且奥拉西坦组MMSE[(21.52±7.83)分比(16.75±6.27)分]、BI[(88.17±11.39)分比(79.97±13.36)分]分值明显高于常规治疗对照组(P<0.05)。结论:奥拉西坦可显著改善脑梗死患者的认知功能。

Objective： To evaluate clinical effects of oxiracetam on improvement of cognition in patients with cerebral infarction. Methods： A total of 96 patients with cerebral infarction were randomly and equally divided into oxiracetam group （received treatment with oxiracetam based on routine treatment） and routine treatment control group （re- ceived routine treatment）. Mini-mental state examination （MMSE） and Barthel index （BI） were used to measure cognition condition of the two groups before and after treatment, and the results were compared and analyzed. Resalts： After one month treatment, scores of MMSE and BI significantly increased in the two groups compared with before treatment （P〈0.05-〈0.01）, and scores of MMSE and BI in oxiracetam group were significantly higher than those of routine treatment control group [MMSE （21.52±7.83） scores vs. （16.75±6.27） scores, BI （88.17± 11.39） scores vs. （79.97± 13.36） scores, P〈0.05 both]. Conclusion： Oxiracetam can significantly improve cognition of patients with cerebral infarction.