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脂蛋白相关磷脂酶A2的研究进展 被引量:14

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摘要 动脉粥样硬化(AS)是一种炎症性疾病,脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipaseA2,Lp-PLA2)是心血管疾病中一种新的炎症酶,能水解氧化低密度脂蛋白(LDL),产生溶血磷脂酰胆碱(lysophosphatidyl-choline,Lyso-PC)和氧化型游离脂肪酸(oxidizedfreefat-tyacids,ox-FA),促进动脉粥样硬化的形成和发展,其与临床疾病的关系日益受到关注。
出处 《心血管康复医学杂志》 CAS 2011年第6期599-601,共3页 Chinese Journal of Cardiovascular Rehabilitation Medicine
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参考文献13

  • 1Kolodgie FD, Burke AP, Skorija KS, et al. Lipoprotein-associ- ated phospholipaseA2 protein expression in the natural progres- sion of human coronary atherosclerosis [J]. Arterioscler Thromb Vasc Biol, 2006, 26 (11): 2523-2529.
  • 2Jang Y, Kin OY, Koh SJ, et al. The Val279Phe variant of the lipoprotein-associated phospholipaseA2 gene is associated with catalytic activities and cardiovascular disease in Korean men [J]. J Clin Endocrinol Metab, 2006, 91 (9): 3521 -3527.
  • 3Koenig W, Twardella D, Brenner H, et al. Lipoprotein -asso- ciated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflaramation, renal function, and he modynamic stress [J]. Arterioscler Thromb Vasc Biol, 2006, 26 (7): 1586-1593.
  • 4刘甲兴,郑兴,秦永文,丁继军,赵仙先,曹江.脂蛋白相关性磷脂酶A_2活性能反映冠状动脉粥样硬化病变程度[J].第二军医大学学报,2006,27(4):391-395. 被引量:31
  • 5Sutton BS, Crosslin DR, Shah SH, et al. Comprehensive genetic a- nalysis of the platelet activating factor acetylhydrolase (PLA2GT) gene and cardiovascular disease in case-control and family datasets [J]. Hum Mol Genet, 2008,17(9) : 1318- 1328.
  • 6Hou L, Chen, S, Yu H, et al. Associations of PLA2G7 gene polymorphisms with plasma lipoprotein- associated phospho- lipase A2 activity and coronary heart disease in a Chinese Han population: the Beijing atherosclerosis study [J]. Hum Genet, 2009, 125 (1): 11-20.
  • 7Ninio E, Tregouet D, Carrier JL, et al. PAF-AH and PAF- receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease [J]. Hum Mol Genet, 2004, 13 (13): 1341-1351.
  • 8Liu PY, Chung HC, Chen JY, et al. Platelet-activating factor -acetylhydrolase (PLA2GT) A379V (Exon 11) gene polymor- phism is functionally associated with coronary artery disease se- verity but not onset of acute coronary syndrome [J]. Acta Car- diolSin, 2006, 22: 212-220.
  • 9Kokubo Y, Tomoike H, Tanaka C, et al. Association of sixty- one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension [J]. Hypertens Res, 2006, 29 (8): 611-619.
  • 10Suzuki T, Solomon C, Jenny NS, et al. Lipoprotein-associat- ed phospholipase A (2) and risk of congestive heart failure in ol- der adults: the Cardiovascular Health Study [J]. Circ Heart Fail, 2009, 2 (5): 429-436.

二级参考文献11

  • 1马丽萍,秦永文,郑兴,吴弘,丁继军,赵仙先,郭品娥.高敏感C反应蛋白和淀粉样物质A与冠状动脉病变程度的关系[J].第二军医大学学报,2004,25(7):763-765. 被引量:4
  • 2Libby P,Ridker PM,Maseri A.Inflammation and atherosclerosis[J].Circulation,2002,105:1135-1143.
  • 3Danesh J,Wheeler JG,Hirschfield GM,et al.C reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease[J].N Engl J Med,2004,350:1387-1397.
  • 4Ridker PM,Stampfer MJ,Rifai N.Novel risk factors for systemic atherosclersis:a comprison of C reactive protein,fibrinogen,homocysteins,lipoprotein (a),and standard cholesterol screening as predictors of peripheral arterial disease[J].JAMA,2001,285:2481-2485.
  • 5Ridker PM,Rifai N,Stampfer M J,et al.Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men[J].Circulation,2000,101:1767-1772.
  • 6Ridker PM,Hennekens CH,Roitman Johnson B,et al.Plasma concentration of soluble intercellular adhesion molecule 1and risks of future myocardial infarction in apparently healthy men[J].Lancet,1998,351:88-92.
  • 7Packard CJ,O'Reilly DS,Caslake MJ,et al.Lipoprotein-associated phospholipase A2as an independent predictor of coronary heart disease.West of Scotland Coronary Prevention Study Group[J].NEnglJ Med,2000,343:1148-1155.
  • 8Koenig W,Khuseyinova N,Lowel H,et al.Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C reactive protein in apparently healthy middleaged men from the general population:results from the 14-year follow up of a large cohort from southern Germany[J].Circulation,2004,110:1903-1908.
  • 9Oei HH,van der Meer IM,Hofman A,et al.Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke:the Rotterdam Study[J].Circulation,2005,111:570-575.
  • 10Caslake MJ,Packard CJ,Suckling KE,et al.Lipoprotein-associated phospholipase A2,platelet activating factor acetyl hydrolase:a potential new risk factor for coronary artery dis ease[J].Atherosclerosis,2000,150:413-419.

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