冠心病患者冠状动脉呈弥漫病变的临床特点分析

Clinical Characteristics of Patients with Diffuse Coronary Heart Disease

随着我国经济的发展和人口老龄化的进程,冠心病发病率逐年升高,同时冠状动脉造影检查发现多支弥漫病变呈增多趋势。冠状动脉弥漫病变患者不仅在再血管化方面需要更多的医疗经费,而术后再狭窄发生率明显增高,有些由于血管全程弥漫狭窄。

Objective To analyze the clinical characteristics of patients with diffuse coronary heart disease. Methods A total of 454 patients with angiographicly confirmed coronary artery disease were retrospectively analyzed, based upon the coronery disease characteristics of angiography. These patients were divided as group Ⅰ （277 patients with diffuse coronery artery disease）, group Ⅱ（277 patients with nondiffuse coronery artery disease）. The clinical documents, laboratory examination data and coronary angiographies results were compared between group I and group II patients. Results Compared to group Ⅱ, the patients of group I had higher rates of diabetes （40.5% vs. 27.3%,P〈0.01）. Serum HDL levels and ApoA levels were significantly lower （HDL, 1.14±0.27 vs. 1.2±0.30, P 〈 0.05 ; ApoA, 1.08±0.11 vs 1.12±0.11, P 〈 0.01）, while concentrations of blood ereatinine was higher（92.76±43.54 vs. 83.01±20.82, P=0.00l）in group Ⅰ. Compared to group Ⅱ, the prevalence of three-vessels comnery artery disease were more common in group I（45.4% vs. 14.5%, P 〈 0.001）. Conclusions The present study supports the evidence that diabetes mellitns,low serum HDL levels and low APOA levels are important risk factor for more extensive and severity coronary artery atheroscleosis disease.