摘要
目的研究父系表达基因10(PEG10)在肝细胞癌中的表达及其临床意义。方法收集2006年3月至2011年5月52例肝细胞癌组织,采用免疫组织化学法检测组织中PEG10表达,分别以31例癌旁组织、10例正常肝组织标本和10例胎盘组织作为对照。回顾52例肝细胞癌患者各项指标检测结果,并分析各项指标与PEG10表达的关系。结果 PEG10在肝细胞癌组织中阳性表达率为90.38%(47/52),显著高于癌旁正常组织[67.74%(21/31)]和正常肝组织(0),差异有统计学意义(P<0.01)。PEG10表达的阳性程度与肝细胞的分化程度呈正相关(r=0.441,P<0.01)。PEG10表达在肿瘤大小、不同年龄和性别患者间比较,差异无统计学意义(P>0.05)。结论 PEG10在肝细胞癌组织中表达的阳性程度与肿瘤分化程度有关,对肝细胞癌的敏感性好,但其特异性不强。
Objective To investigate the expression of PEG10 as HCC cell marker in human hepatocellular carcinoma tissues and its clinical significance. Methods From March 2006 to May 2011,52 paraffin samples of human hepatocellular carcinoma tissues were obtained, and the expression of PEG10 was examined by immunohistochemical staining. Another 31 normal tissues adjacent to human hepatocellular carcinoma and 10 normal liver tissues and 10 normal placenta tissues were served as controls. The clinicopathological data of 52 patients with hepatocellular carcinoma were retrospectively analyzed, and their relationship with the expression of PEG10 was analyzed. Results The positive expression rate of PEG10 in human hepatocellular carcinoma tissues was 90.38% （47/52）, which was significantly higher than that in normal tissues adjacent to human hepatocellular carcinoma（67. 74%,21/31） and nor mal liver tissues（0）（P〈0.01）. The expression of PEG10 was positively correlated with the different differentiation of hepatocellular carcinoma（r= 0. 441,P〈0.01）. There was no significant difference in the expression of PEG10 a mong patients with the different differentiation of tumor size age and gender（P〉0.05）. Conclusion The expression of PEG10 is correlated with the pathology＇ stage. The sensitivity of hepatocellular carcinoma is good, but its specificity is not strong.
出处
《检验医学与临床》
CAS
2011年第24期2951-2953,共3页
Laboratory Medicine and Clinic
基金
上海市宝山区科委基金资助项目(08-E-26)
