急性心肌梗死患者血浆B型钠尿肽及血清心肌梗死指标变化的临床分析

The clinical analysis of the changes of plasma BNP and serum acute myocardial infarction(AMI) indexes in patients with AMI

目的探讨急性心肌梗死(AMI)患者血浆B型钠尿肽(BNP)与其他AMI生化指标之间有无相关性。方法采用免疫荧光法定量检测40例健康体检者及47例AMI患者的BNP,并同时检测其他几项AMI生化指标,进行比较分析及相关分析。结果 (1)AMI组血浆BNP、肌酸激酶同工酶(CK-MB)、肌钙蛋白I(TnI)及肌红蛋白(MYO)检测结果分别为(856.8±295.7)ng/L、(41.71±13.25)μg/L、(0.520±0.180)μg/L、(6.8±16.8)μg/L,健康对照组分别为(165.4±40.6)ng/L、(3.27±1.48)μg/L、(0.010±0.005)μg/L、(22.2±8.7)μg/L,两组比较差异均有统计学意义(P<0.05)。(2)AMI患者血浆BNP与其他AMI指标的相关性分析结果表明,血浆BNP与CK-MB、TnI和MYO之间呈正相关。结论血浆BNP可作为临床预测冠心病患者发生AMI危险性的指标,并可与CK-MB、TnI及MYO一起作为AMI的监测及疗效观察的指标。

Objective To analyze the correlation between plasma B-type natriuretic peptide （BNP）and acute myocardial infarction （AMI） indexes in patients with AMI. Methods Serum BNP was measured by immunofluorescenee assay in 40 healthy persons as well as 47 AMI patients,and the AMI indexes were also tested and analyzed at the same time. Results （1）Compared with the healthy group,the levels of plasma BNP,myoglobin（MYO） ,troponin I（TnI） and serum creatine kinase isoenzyme （CK-MB） were signifiicantly higher than those of the AMI patients （P〈 0.05）. （2） In patients with AMI, significant positive correlation was found between plasma BNP and CK-MB, TnI, and MYO（P〈0.05）. Conclusion Plasma BNP can serve as a predictor of AMI. It is also a valuable index along with CK-MB,TnI,and Myo for prognosis monitoring and curative effect .