社区相关耐甲氧西林金黄色葡萄球菌感染分析

Analysis on the infection of community-associated methicillin-resistant staphylococcus aureus

目的了解社区相关耐甲氧西林金黄色葡萄球菌(CA-MRSA)感染分布特点及耐药现状。方法参照美国疾病预防控制中心对CA-MRSA判断标准,回顾性分析2008～2010清远市人民医院分离的CA-MRSA感染分布特点,采用WHONET5.4软件统计耐药数据。结果 2008～2010年共分离到CA-MRSA 31株,占MRSA分离株(73株)的42%;CA-MRSA感染患者平均年龄为15岁,主要引起皮肤软组织感染(94%),对环丙沙星、高水平莫匹罗星、庆大霉素、阿米卡星、复方新诺明、利福平、万古霉素、利奈唑烷、奎奴普丁/达福普汀、替考拉宁耐药率为0,对红霉素、克林霉素、四环素耐药率分别为94%、94%、45%。结论加强对CA-MRSA的监测十分必要。

Objective To understand the distribution features and the drug resistance status of community-associated methicillin-resistant staphylococcus aureus （CA-MRSA）. Methods According to the criteria of CA MRSA proposed by America CDC,we made a retrospective study of the distribution features of CA-MRSA isolated in our hospital during 2008 to 2010. The resistance data was analyzed with WHONETS. 4 software. Results Among 73 strains of MRSA isolated in our hospital during 2008 to 2010,CA-MRSA accounted for 42 % （31 strains）. The mean age of the CA-MRSA infection patients was 15 years. Most（94%） of CA-MRSA were caused by skin and soft tissue infection. The resistance rate of CA-MRSA to Ciprofloxacin, Mupiroein high level, Gentamicin, Amikacin, Trimethoprim/Sulfamethoxazole,Rifampin, Vancomycin, Linezolid, Quinupristin/Dalfopristin, Teicoplanin was 0, and the resistance rate of CA-MRSA to Erythromycin Tetracycline was 94%,94%,45% ,respectively. Conclusion It is very necessary to strengthen the monitoring of CA-MRSA.