溃疡性结肠炎患者血小板计数及凝血功能检测的临床意义

Detection and clinical significance of blood platelets count and Coagulation in patients with ulcerative colitis

目的探讨检测溃疡性结肠炎患者血小板计数和凝血功能的临床意义。方法检测68例溃疡性结肠炎患者及26例对照组血小板计数及凝血功能，分析两者对患者临床病情程度的影响及其相关性。结果活动期溃疡性结肠炎患者血小板计数及纤维蛋白原明显高于缓解期患者和对照组（P〈0．05），凝血酶原时间明显低于缓解期患者和对照组（P〈0．05）。重度溃疡性结肠炎患者血小板计数及纤维蛋白原明显高于中、轻度患者（P〈0．05），凝血酶原时间明显低于中、轻度溃疡性结肠炎患者（P〈0．05）。溃疡性结肠炎患者血小板计数与凝血酶原时间变化存负相关，与纤维蛋白原存在正相关。结论血小板计数及凝血功能检测对判断溃疡性结肠炎活动性及其严重程度具有重要临床价值。

Objective To study the detection and clinical signifcance of blood platelets count （BPC） and coagulation in patients with ulcerative colitis （UC）. Methods The levels of peripheral BPC and coagulation in 57 patients with UC and 26 normal control group were detected and the effects on severity of UC were analyzed subsequently. Results The levels of peripheral BPC and Fibrinogen（FIB） in active phase group were significantly higher than those in control group. Prothrombin time（PT） in active phase group was significantly lower than those in control group. The levels of BPC and FIB in severe stage were significantly higher than those in patients medium and mild stage, PT in severe stage were significantly lower than those patients in medium and mild stage. In patients with UC, BPC were correlated with FIB and were negative correlated with PT. Conclusion It is proposal that BPC and coagulation would provide useful marker of active of UC. They are important to judge active phase and severity of UC.