卡巴胆碱对重症患者的治疗价值

The value of carbachol on the treatment of critical patients

目的:探讨卡巴胆碱在重症患者治疗中的临床价值。方法:选取2008年1月-2010年12月唐山市3家三级医院ICU重症患者300例。随机分为卡巴胆碱组(182例)和正常治疗组(118例)。正常治疗组包括液体复苏、氧疗、禁食、止痛、胃肠减压、器官功能维护等;卡巴胆碱组在常规治疗的基础上给予卡巴胆碱肌肉注射,每次0.2mg·kg-1,每日2次。于治疗前(0h),治疗后24,48,72,96h或患者死亡前观察2组患者胃肠功能评分和血清CRP及IL-6的变化。结果:卡巴胆碱可以减低胃肠功能评分、改善肠道功能;抑制炎症因子释放,降低炎症反应。结论:卡巴胆碱在重症患者治疗中具有一定的临床价值。

OBJECTIVE To study the value of carbachol in the treatment of critical patients. METHODS From January 2008 to December 2010 in Tangshan three tertiary rank hospitals ICU, 300 patients with severe pancreatitis, were randomly divided into carbachol group （182 cases） and control group （118 cases）. The treatment of controlnormal group included fluid resuscitation, oxygen therapy, fasting, relieving pain, gastrointestinal decompression, maintenance of organ function; carbachol group was treated on the basis of given intramuscular injection of carbachol, 0. 2 mg.kg-1 , 2 times a day. Before treatment （0h）, after treatment, 24,48,72 h, 96 h or before death, the patients gastrointestinal function, and the changes of serum CRP, IL-6 were observed. RESULTS Carbachol can could reduce the rate scores of gastrointestinal function, improve bowel function; inhibit inflammatory cytokine release and reduce inflammation. CONCLUSION Carbachol used for the treatment of critical patients has some clinical values. CONCLUSION Carbachol on the treatment of critical patients has some clinical value.