不同间断光疗方法治疗新生儿ABO溶血病临床效果对比分析

目的比较不同间断光疗方法治疗新生儿ABO溶血病临床效果。方法将112例未达换血标准的新生儿ABO溶血病患儿随机分为两组。分次光疗组59例,每次双面蓝光照射6h,间隔6h后重复照射,疗程5d。单次光疗组53例,每天连续双面光疗12h,疗程5d。累计光疗时间均为60h。比较两组的黄疸治疗效果以及副作用发生率。结果两组光疗前后胆红素水平比较差异均有统计学意义(分次光疗组t=21.83,P<0.01;单次光疗组t=22.32,P<0.01)。光疗前两组总胆红素水平比较差异无统计学意义(t=-0.598,P>0.05),但光疗后两组胆红素水平比较差异有统计学意义(t=-7.44,P<0.01)。结论两种间断光疗方法治疗新生儿ABO溶血病均有效。分次光疗治疗效果好,副作用小。

Objective To compare the effect of different interval phototherapy method on hemolytic disease of the newborn（HDN） due to A and B incompatibility.Methods 112 neonates with HDN were randomly divided into two groups.group A was given 12 hours continuous phototherapy once a day,for 5 consecutive days;group B was given 6 hours phototherapy twice a day for 5 consecutive days.The effect and the side effect between the two group were analyzed and compared.Results There were no statistical differences in bilirubin levels before the treatment between the two groups（P0.05）,while significant differences were recorded after therapy（P0.01）.After treatment,the difference of total bilirubin levels and side effects between the two groups was significant（P0.01）.Conclusion The two therapeutic modalities are all effective for HDN.The phototherapy at 6 hours interval was more effective and feasible.