HIF-1α及转录因子Snail与直肠癌侵袭转移及预后的关系

Expression of Hypoxia-inducible-factor-1α and Transcriptional Factor Snail in Rectal Cancer Induces Metastasis and Poor Prognosis

目的探讨HIF-1α与转录因子Snail在直肠癌中的表达,分析其与直肠癌侵袭转移的关系,评估预后。方法采用免疫组织化学SABC法检测121例直肠癌组织中HIF-1α与Snail的表达,分析两者在不同的临床病理分期与分化程度的直肠癌中的表达及其与预后的关系。结果免疫组织化学检测结果显示直肠癌组织中HIF-1α、Snail的阳性表达率分别为58.7%(71/121)、71.9%(87/121),HIF-1α与Snail的表达与直肠癌的TNM综合分期、淋巴结转移及生存率有关(P<0.05)。HIF-1α与Snail的表达呈显著正相关(P<0.05)。结论 HIF-1α、Snail蛋白的高表达可能是促进直肠癌侵袭转移的重要生物学标志。

Objective To investigate the expression of HIF-1α and Snail proteins in rectal cancer and their significance in metastasis and prognosis.Methods The expression of HIF-1α and Snail proteins was detected by using immunohistochemical SABC method in 121 cases of rectal cancer tissues.Results The positive rates of HIF-1α and Snail in rectal cancer were 58.7%（71/121） and 71.9%（87/121）,respectively the expression of HIF-1α and Snail were significantly related with the lymph node metastasis and TNM stage of rectal cancer（P0.05）.HIF-1α expression have significantly positive correlation with Snail expression（P0.05）.Conclusion The overexpression of HIF-1α and Snail might be important biological marker for invasion and metastasis and prognosis of rectal carcinoma.