1305例体检人群心踝血管指数影响因素探讨

Influencing factors of cardio-ankle vascular index in 1305 subjects for health-care examination

目的探讨体检人群心踝血管指数(cardio-ankle vascular index,CAVI)的影响因素。方法对1 305例体检人群进行血压、身高、体重的测量,并计算出体质指数,采集空腹静脉血分析血脂、血糖等生化指标,采用动脉硬化检测仪测量CAVI值,并对以上指标进行统计分析。结果①CAVI正常组和升高组相比,年龄、性别、收缩压、舒张压、脉压和血糖的差异均有统计学意义(均有P<0.05);②将血脂按不同水平分组后,不同水平的甘油三酯各组间CAVI阳性率的差异有统计学意义(P<0.05);③采用多元逐步Logistic回归分析结果表明:年龄、收缩压、甘油三酯、高密度脂蛋白、体质指数及血糖是影响CAVI的独立因素(均有P<0.05),其中高密度脂蛋白及体质指数与CAVI呈负相关关系。结论年龄、收缩压、甘油三酯及血糖的增高是影响动脉僵硬度的主要危险因素,而高密度脂蛋白对血管弹性有轻微保护作用。体质指数并不能准确反映肥胖与动脉僵硬度的关系,应关注腹型肥胖对血管弹性的影响。

Objective To explore the influencing factors of cardio-ankle vascular index（CAVI） in subjects for health-care examination.Methods 1 305 subjects for health-care examination were recruited in our study.Blood pressure,height and weight of everyone were measured,and body mass index（BMI） was calculated.All subjects were measured blood lipids,glucose and other biochemical indicator.The cardio-ankle vascular index of each person was tested by arteriosclerosis diagnostic instrument.The data was analyzed by statistical package.Results There was significant difference between groups of normal CAVI and increased CAVI on age,sex,systolic pressure,diastolic pressure,pulse pressure and blood glucose（P0.05）.Lipids was separated into different groups according to the different level.There was significant difference between groups of triglyceride on the positive rate of CAVI（P0.05）.Multiple factors analysis revealed that the independent factors which influenced CAVI included age,systolic pressure,triglyceride,high density lipoprotein-cholesterol（HDL-C）,BMI and blood glucose（P0.05）.Both of HDL-C and BMI were negatively correlated with CAVI.Conclusions The risk factors that affected the elasticity of blood vessels were age,systolic pressure,triglyceride and blood glucose.HDL-C had a slightly protective effect on the elasticity of blood vessels.BMI could not accurately reflect the relationship between obesity and the elasticity of blood vessels.We should focus on the effects on the elasticity of blood vessels caused by intraabdominal fat.