脂肪因子visfatin与动脉粥样硬化性脑梗死的关系

Correlation of adipokine visfatin and atherosclerotic ischemic cerebrovascular disease

目的探讨血清visfatin水平与动脉粥样硬化性脑梗死的关系。方法选取急性脑梗死患者60例,按IMT厚度、斑块的回声特征分为无动脉粥样硬化组(B1组)21例、稳定型斑块组(B2组)17例和不稳定型斑块组(B3组)22例。另取健康查体者35例为对照(A组)。酶联免疫吸附试验测定各组血清visfatin水平,并行NIHSS功能评定,分析visfatin与动脉粥样硬化性脑梗死的关系。结果 visfatin水平B1、B2、B3组高于A组(P均<0.01),B3组高于B1、B2组(P<0.01)。visfatin水平与NIHSS评分正相关(r=0.47,P<0.01)。结论血清高水平visfatin与脑梗死的发病相关,visfatin可作为动脉粥样硬化的独立危险因素。

Objective To explore the correlation of visfatin and atherosclerotic ischemic cerebrovascular disease. Methods A total of 60 acute cerebral infarction（ACI） patients were enrolled, and divided into no artherosclerosis group （group B1, n = 21 ） , stable artherosclerosis group（group B2, n = 17） and unsteadiness artherosclerosis group（ group B3, n = 35 ）. A total of 35 healthy were enrolled as control group （ group A）. Serum visfatin levels were detected by ELISA method. NIHSS score was evaluated, and the correlation between visfatin and artherosclerosis cerebral infarction was analyzed. Results The levels of visfatin in group B1, B2, B3 were higher than those of group A （ all P 〈 0.01 ） , those of group B3 higher than those of group B1, B2 （P 〈 0.01 ）. Correlation and regression analysis showed the contents of visfatin was positivly correlate to NIHSS score （ r = 0.47, P 〈 0.01 ）. Conclusions High levels of visfatin may be related with the pathogenesy of cerbral infarction, visfatin can be the independent risk factor of artherosclerosis.