胰岛素联合磺胺嘧啶银乳膏在糖尿病足治疗中的应用

Application of regular insulin combining silvadene cream in the treatment for diabetic foot ulcer

目的探讨胰岛素溶液与磺胺嘧啶银(SD-Ag)乳膏联合治疗糖尿病足(DF)溃疡的疗效。方法DF患者120例,随机分为4组:胰岛素溶液+SD-Ag乳膏组(A组)、SD-Ag乳膏组(B组)、0.1%乳酸依沙吖啶溶液组(C组)和胰岛素溶液组(D组),各30例,经局部创面换药治疗,直至创面愈合;将4组病例的创面愈合时间进行比较。结果 A组和B组比C组和D组创面愈合时间明显缩短,差异有统计学意义,而且A组的创面愈合时间最短,与B组相比,差异也有统计学意义(P均<0.05)。但是,C组和D组相比,差异无统计学意义(P>0.05)。结论胰岛素溶液与SD-Ag乳膏联合治疗DF能明显缩短疗程,值得临床推广。

Objective To observe the effect of regular insulin combining silvadene（SD-Ag） cream on diabetic foot ulcer.Methods 120 patients with diabetic foot were randomly divided into 4 groups： group A receiving regular insulin＋SD-Ag cream,group B receiving SD-Ag cream,group C receiving 0.1%lactic acid solution ethacridine,group D receiving regular insulin,with 30 patients in each group.The local ulcer dressing was changed until the wounds healed.The wound healing time was compared between the 4 groups.Results The wound healing time of group A and group B was significantly shorter than that in group C and group D.Between group A and group B,there was significant difference in wound healing time（P〈0.05）.Conclusions Insulin and SD-Ag treatment for diabetic foot can significantly shorten the treatment course,which is worthy of promotion.